MRI-based 3D texture and shape analysis were performed to evaluate the detectable differences between the two malignancies. To investigate the diagnostic value of magnetic resonance imaging (MRI)-based 3D texture and shape features in the differentiation of glioblastoma (GBM) and primary central nervous system lymphoma (PCNSL).Ī total of eighty-two patients, including sixty patients with GBM and twenty-two patients with PCNSL were followed up retrospectively from January 2012 to September 2017. The authors would like to acknowledge Memduh Dursun, MD, for his kind assistance during analysis of the MR data. For automated ROI placement, the suspected regions must be volumetrically segmented, which is a Acknowledgments Placement of these ROIs is critical and requires much experience to achieve reproducible results. In clinical practice, lesion enhancement analysis starts by manually placing a couple of 2D ROIs on the most suspicious areas of the early postcontrast images that show high enhancements after a visual inspection of the acquired images, and only a few measurements are used to assess a 3D lesion. The projection is passed through a threshold to differentiate the suspicious lesion appropriately while eliminating false Discussion Relative contrast enhancements are calculated using a voxel sampling method based on a moving 3 × 3 mask and a 3D nMITR projection is generated for the VOI. A semiautomated method is used to identify the lesion inside a rectangular prism VOI roughly marked by an expert. The imaging sequence was a variant of spoiled gradient-echo imaging, T1-weighted 3D fast low angle shot (FLASH, TR/TE 9.80/4.76 msec, flip angle Resultsįifty-two breast lesions identified from high-resolution MR images of 46 patients are studied. Patients were placed in a prone position during the scan to minimize motion artifacts. A dedicated four-element phased-array receiver breast coil was used. Magnetic resonance imaging was conducted on a 1.5-T MR imager (Magnetom Symphony Siemens Medical Systems, Erlangen, Germany) equipped with a gradient system having a maximum amplitude of 30 mT/m.
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